Journal of Applied Toxicology dergisinden;
Alıntı:
Cytotoxicity on human cells of Cry1Ab and Cry1Ac Bt insecticidal toxins alone or with a glyphosate-based herbicide
R. Mesnage, E. Clair, S. Gress, C. Then, A. Székács, G.-E. Séralini
Article first published online: 15 FEB 2012
Keywords:
Roundup;Bt toxins;Cry1Ab;Cry1Ac;GMOs;mixtures;glyphosate;huma n cells
ABSTRACT
The study of combined effects of pesticides represents a challenge for toxicology. In the case of the new growing generation of genetically modified (GM) plants with stacked traits, glyphosate-based herbicides (like Roundup) residues are present in the Roundup-tolerant edible plants (especially corns) and mixed with modified Bt insecticidal toxins that are produced by the GM plants themselves. The potential side effects of these combined pesticides on human cells are investigated in this work. Here we have tested for the very first time Cry1Ab and Cry1Ac Bt toxins (10 ppb to 100 ppm) on the human embryonic kidney cell line 293, as well as their combined actions with Roundup, within 24 h, on three biomarkers of cell death: measurements of mitochondrial succinate dehydrogenase, adenylate kinase release by membrane alterations and caspase 3/7 inductions. Cry1Ab caused cell death from 100 ppm. For Cry1Ac, under such conditions, no effects were detected. The Roundup tested alone from 1 to 20 000 ppm is necrotic and apoptotic from 50 ppm, far below agricultural dilutions (50% lethal concentration 57.5 ppm). The only measured significant combined effect was that Cry1Ab and Cry1Ac reduced caspases 3/7 activations induced by Roundup; this could delay the activation of apoptosis. There was the same tendency for the other markers. In these results, we argue that modified Bt toxins are not inert on nontarget human cells, and that they can present combined side-effects with other residues of pesticides specific to GM plants. Copyright © 2012 John Wiley & Sons, Ltd.
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Caen Üniversitesinde yapılan araştırmanın 15 Şubat 2012 tarihinde yayınlanan bilimsel makaleye göre GDO'lu ürünlerdeki BT toksininin Monsanto'nun bugüne kadar iddia ettiği üzere sadece hedef böcekte aktif olup insan ve diğer memelilere bir etkisinin olmadığı savı çürütülmüş oluyor.
Bu araştırmaya göre GDO'larda bulunan BT toksininin insan hücrelerini tahrip edebileceği anlaşılmış oluyor.
Aynı çalışmada glyphosate (roundup) içeren ot ilacının çok küçük bir dozunun dahi, bu konuda yapılmış başka araştırmalarda da belirlendiği gibi insan hücrelerinde tahribat yaptığını göstermiş.
Çok özetle bu araştırmayı yapan bilim insanları diyor ki;
GDO'larda bulunan modifike edilmiş BT toksinleri aslında hedef olmayan insan hücrelerinde etkisiz ve eylemsiz değildir ve GDO'lu bitkilere özel pestisit kalıntılarıyla birlikte ilave yan etkiler gösterebilir.